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Clin Colon Rectal Surg
DOI: 10.1055/s-0044-1801391
Review Article

Personalizing Perioperative Chemotherapy in Colon Cancer

Joyce H. Pang
1   Department of Surgery, Oregon Health and Science University, Portland, Oregon
,
Charles A. Baldi III
1   Department of Surgery, Oregon Health and Science University, Portland, Oregon
,
Daniel O. Herzig
1   Department of Surgery, Oregon Health and Science University, Portland, Oregon
› Author Affiliations Funding None.
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Abstract

The traditional, surgery-first approach for colon cancer is increasingly challenged by our evolving understanding of tumor biology and a growing number of measurable tumor features that can help guide contemporary treatment plans. Certain tumor characteristics now make it practical to challenge locally advanced colon cancer with neoadjuvant chemotherapy or immunotherapy, and allow for targeted postoperative therapies. The contemporary data supporting these tailored approaches to integrating systemic therapy before or after resection are summarized in this article.

Keywords

colon cancer - chemotherapy - microsatellite instability - next-generation sequencing


Publication History

Article published online:
15 January 2025

© 2025. Thieme. All rights reserved.

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