Subscribe to RSS
DOI: 10.1055/s-0044-1801819
Technical Review of Lithotripsy Devices for Percutaneous Management of Biliary Stones: A Guide for Interventional Radiologists

Abstract
This review provides a comprehensive overview of intracorporeal lithotripsy techniques, focusing on laser and electrohydraulic lithotripsy, for the management of biliary tract stones. Biliary stones pose a significant health concern, affecting a notable percentage of the adult population, with potentially life-threatening complications. Minimally invasive approaches, such as lithotripsy, offer advantages over traditional, open surgical methods, including reduced risk of complications, shorter hospital stays, and faster recovery times. Laser lithotripsy employs light emission and amplification to fragment stones, while electrohydraulic lithotripsy generates shockwaves from a bipolar probe tip for fragmentation. Solid-state lasers like holmium and thulium fiber lasers are considered the gold standard, with recent advancements enhancing their efficiency and safety profiles. Safety precautions and patient preparation are essential for successful outcomes. Future directions for platform utilization may focus on optimizing parameters, exploring new therapeutic indications, and refining fiber designs. Overall, intracorporeal lithotripsy techniques represent valuable options for biliary stone management, improving patient care and quality of life through a minimally invasive approach.
Declarations
H.S. is a consultant to Cook Medical and Inari. The other authors declare no conflicts of interest.
Ethical Considerations
Not applicable
Publication History
Received: 07 December 2024
Accepted: 17 December 2024
Article published online:
29 January 2025
© 2025. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver 2012; 6 (02) 172-187
- 2 Lammert F, Gurusamy K, Ko CW. et al. Gallstones. Nat Rev Dis Primers 2016; 2: 16024
- 3 Rothschild JG, Holbrook RF, Reinhold RB. Gallstone lithotripsy vs cholecystectomy. A preliminary cost-benefit analysis. Arch Surg 1990; 125 (06) 710-713 , discussion 713–714
- 4 Scotland KB, Kroczak T, Pace KT, Chew BH. Stone technology: intracorporeal lithotripters. World J Urol 2017; 35 (09) 1347-1351
- 5 Kronenberg P, Somani B. Advances in lasers for the treatment of stones - a systematic review. Curr Urol Rep 2018; 19 (06) 45
- 6 Helfmann J, Müller G. Laser lithotripsy: process and overview. Med Laser Appl 2001; 16 (01) 30-37
- 7 Tzelves L, Somani B, Berdempes M, Markopoulos T, Skolarikos A. Basic and advanced technological evolution of laser lithotripsy over the past decade: an educational review by the European Society of Urotechnology Section of the European Association of Urology. Turk J Urol 2021; 47 (03) 183-192
- 8 Kronenberg P, Traxer O. Update on lasers in urology 2014: current assessment on holmium:yttrium-aluminum-garnet (Ho:YAG) laser lithotripter settings and laser fibers. World J Urol 2015; 33 (04) 463-469
- 9 Kronenberg P, Traxer O. In vitro fragmentation efficiency of holmium: yttrium-aluminum-garnet (YAG) laser lithotripsy–a comprehensive study encompassing different frequencies, pulse energies, total power levels and laser fibre diameters. BJU Int 2014; 114 (02) 261-267
- 10 Delbarre B, Baowaidan F, Culty T. et al. Prospective comparison of thulium and holmium laser lithotripsy for the treatment of upper urinary tract lithiasis. Eur Urol Open Sci 2023; 51: 7-12
- 11 Hsiao YC, Chang CJ. Update on flashlamp pumped pulsed dye laser treatment for port wine stains (capillary malformation) patients. Laser Ther 2011; 20 (04) 265-272
- 12 Poetke M, Philipp C, Berlien HP. Flashlamp-pumped pulsed dye laser for hemangiomas in infancy: treatment of superficial vs mixed hemangiomas. Arch Dermatol 2000; 136 (05) 628-632
- 13 Pishchalnikov YA, Behnke-Parks WM, Stoller ML. Plasma formation in holmium:YAG laser lithotripsy. Lasers Surg Med 2023; 55 (05) 503-514
- 14 Spindel ML, Moslem A, Bhatia KS. et al. Comparison of holmium and flashlamp pumped dye lasers for use in lithotripsy of biliary calculi. Lasers Surg Med 1992; 12 (05) 482-489
- 15 Das AK, Chiura A, Conlin MJ, Eschelman D, Bagley DH. Treatment of biliary calculi using holmium: yttrium aluminum garnet laser. Gastrointest Endosc 1998; 48 (02) 207-209
- 16 Itzkan I, Albagli D, Dark ML, Perelman LT, von Rosenberg C, Feld MS. The thermoelastic basis of short pulsed laser ablation of biological tissue. Proc Natl Acad Sci U S A 1995; 92 (06) 1960-1964
- 17 Chan KF, Vassar GJ, Pfefer TJ. et al. Holmium:YAG laser lithotripsy: a dominant photothermal ablative mechanism with chemical decomposition of urinary calculi. Lasers Surg Med 1999; 25 (01) 22-37
- 18 Fried NM, Irby PB. Advances in laser technology and fibre-optic delivery systems in lithotripsy. Nat Rev Urol 2018; 15 (09) 563-573
- 19 Adkins WC, Dulabon DA, Chorazy ZJ, Lund PS, Johnson LM, Jones WV. Consider Ho:YAG for low-cost, effective laser lithotripsy. Clin Laser Mon 1994; 12 (09) 139-141
- 20 Sourial MW, Knudsen BE. Ho:YAG laser lithotripsy. In: Schwartz BF, Denstedt JD. eds. Ureteroscopy: A Comprehensive Contemporary Guide. Cham: Springer International Publishing; 2020: 101-112
- 21 Nazif OA, Teichman JM, Glickman RD, Welch AJ. Review of laser fibers: a practical guide for urologists. J Endourol 2004; 18 (09) 818-829
- 22 Panthier F, Solano C, Chicaud M. et al. Initial clinical experience with the pulsed solid-state thulium YAG laser from Dornier during RIRS: first 25 cases. World J Urol 2023; 41 (08) 2119-2125
- 23 Schembri M, Sahu J, Aboumarzouk O, Pietropaolo A, Somani BK. Thulium fiber laser: the new kid on the block. Turk J Urol 2020; 46 (Suppl. 01) S1-S10
- 24 Jackson SD, Lauto A. Diode-pumped fiber lasers: a new clinical tool?. Lasers Surg Med 2002; 30 (03) 184-190
- 25 Traxer O, Keller EX. Thulium fiber laser: the new player for kidney stone treatment? A comparison with holmium:YAG laser. World J Urol 2020; 38 (08) 1883-1894
- 26 Kronenberg P, Traxer O. The laser of the future: reality and expectations about the new thulium fiber laser - a systematic review. Transl Androl Urol 2019; 8 (Suppl. 04) S398-S417
- 27 Corrales M, Traxer O. Initial clinical experience with the new thulium fiber laser: first 50 cases. World J Urol 2021; 39 (10) 3945-3950
- 28 Smirniotopoulos JB, Jain N, Lamberti M, Marchalik D, McClure T, Browne W. Safety and effectiveness of large-bore percutaneous cholangioscopy-assisted gallstone retrieval for inoperable calculous cholecystitis: a multi-institutional retrospective study. J Vasc Interv Radiol 2024; 35 (12) 1760-1766
- 29 Bratcher J, Kasmin F. Choledochoscopy-assisted intraductal shock wave lithotripsy. Gastrointest Endosc Clin N Am 2009; 19 (04) 587-595
- 30 Watson RR, Parsi MA, Aslanian HR. et al; ASGE Technology Committee. Biliary and pancreatic lithotripsy devices. VideoGIE 2018; 3 (11) 329-338
- 31 Aldoukhi AH, Black KM, Ghani KR. Emerging laser techniques for the management of stones. Urol Clin North Am 2019; 46 (02) 193-205
- 32 Miller DT, Semins MJ. Safety during ureteroscopy: radiation, eyes, and ergonomics. Front Surg 2021; 8: 737337
- 33 Ierardi AM, Rodà GM, Di Meglio L. et al. Percutaneous transhepatic electrohydraulic lithotripsy for the treatment of difficult bile stones. J Clin Med 2021; 10 (07) 1372
- 34 Suzuki N, Takahashi W, Sato T. Types and chemical composition of intrahepatic stones. Prog Clin Biol Res 1984; 152: 71-80
- 35 Burton KE, Picus D, Hicks ME. et al. Fragmentation of biliary calculi in 71 patients by use of intracorporeal electrohydraulic lithotripsy. J Vasc Interv Radiol 1993; 4 (02) 251-256
- 36 Streltsova OS, Vlasov VV, Grebenkin EV. et al. Controlled fragmentation of urinary stones as a method of preventing inflammatory infections in the treatment of urolithiasis (experience in successful clinical use). Sovrem Tekhnologii Med 2021; 13 (03) 55-61
- 37 Aldoukhi AH, Roberts WW, Hall TL, Ghani KR. Holmium laser lithotripsy in the new stone age: dust or bust?. Front Surg 2017; 4: 57
- 38 Ozcan N, Riaz A, Kahriman G. Percutaneous management of biliary stones. Semin Intervent Radiol 2021; 38 (03) 348-355
- 39 Khayat A, Khayat M, Cline M, Riaz A. Percutaneous Biliary Endoscopy. Seminars in Interventional Radiology. New York, NY: Thieme Medical Publishers, Inc.; 2021
- 40 Raijman I, Escalante Glorsky S. Electrohydraulic lithotripsy in the treatment of bile and pancreatic duct stones. In: UpToDate. Waltham, MA: UpToDate Inc.; 2008
- 41 Pu W, Ma C, Wang B. et al. Electrohydraulic lithotripsy through endoscopic retrograde cholangiopancreatography combined with SpyGlass in the treatment of complex pancreatic duct stones: a case report and literature review. Front Surg 2023; 10: 1059595
- 42 Maydeo A, Kwek BE, Bhandari S, Bapat M, Dhir V. Single-operator cholangioscopy-guided laser lithotripsy in patients with difficult biliary and pancreatic ductal stones (with videos). Gastrointest Endosc 2011; 74 (06) 1308-1314
- 43 Jongjitaree K, Subpayakorn C, Taweemonkongsap T, Leewansangtong S, Srinualnad S, Chotikawanich E. The effect of laser fiber on the damage of the working channel of a flexible ureteroscope. Heliyon 2020; 6 (11) e05605
- 44 Giusti G, Pupulin M, Proietti S. Which is the best laser for lithotripsy? The referee point of view. Eur Urol Open Sci 2022; 44: 20-22
- 45 Binh NT, Dung LV, My TT, Duc NM. Percutaneous transhepatic holmium laser lithotripsy for giant biliary stones. J Clin Imaging Sci 2021; 11: 55
- 46 Elsayed M, Nezami N, Kokabi N, Scriver GM, Behairy MM, Majdalany BS. Percutaneous transhepatic cholangioscopy-guided lithotripsy and retrieval of vascular coils eroded into the biliary tree. Radiol Case Rep 2022; 18 (02) 444-448
- 47 Lamanna A, Maingard J, Bates D, Ranatunga D, Goodwin M. Percutaneous transhepatic laser lithotripsy for intrahepatic cholelithiasis: a technical report. J Med Imaging Radiat Oncol 2019; 63 (06) 758-764
- 48 Binh NT, Hoa TQ, My TT, Duc NM. Percutaneous transhepatic holmium laser lithotripsy for cholelithiasis and balloon dilation for common bile duct stone removal. Radiol Case Rep 2022; 17 (07) 2506-2509
- 49 Schlesinger NH, Svenningsen P, Frevert S, Wettergren A, Hillingsø J. Percutaneous yttrium aluminum garnet-laser lithotripsy of intrahepatic stones and casts after liver transplantation. Liver Transpl 2015; 21 (06) 831-837
- 50 Rimon U, Kleinmann N, Bensaid P. et al. Percutaneous transhepatic endoscopic holmium laser lithotripsy for intrahepatic and choledochal biliary stones. Cardiovasc Intervent Radiol 2011; 34 (06) 1262-1266
- 51 Herr A, Collins D, White M. et al. Percutaneous biliary endoscopy for stones. Tech Vasc Interv Radiol 2019; 22 (03) 127-134
- 52 Pang S, England RW, Solomon A, Hong K, Singh H. Single-use versus reusable endoscopes for percutaneous biliary endoscopy with lithotripsy: technical metrics, clinical outcomes, and cost comparison. J Vasc Interv Radiol 2022; 33 (04) 420-426
- 53 Ibrahim A, Elhilali MM, Fahmy N, Carrier S, Andonian S. Double-blinded prospective randomized clinical trial comparing regular and Moses modes of holmium laser lithotripsy. J Endourol 2020; 34 (05) 624-628
- 54 Smirniotopoulos JB, Latich I, Nezami N. Advancing biliary stone management: percutaneous transhepatic endoscopic holmium laser lithotripsy for treatment of cholangiolithiasis and choledocholithiasis. Eur Radiol 2024; 34 (11) 7173-7175
- 55 Katariya N, Mathur AK. Biliary strictures: a surgeon's perspective for interventional radiologists. Semin Intervent Radiol 2021; 38 (03) 273-279
- 56 Trivedi P, Saben JL, Liu L, Malamon JS, Pomfret E, Pshak T. Preliminary safety and efficacy of laser stricturotomy for treatment of refractory biliary anastomotic strictures following liver transplantation. Am J Transplant 2023; 23 (04) 573-576
- 57 Lou J, Hu Q, Ma T, Chen W, Wang J, Pankaj P. A novel approach with holmium laser ablation for endoscopic management of intrahepatic biliary stricture. BMC Gastroenterol 2019; 19 (01) 172
- 58 Kronenberg P, Traxer O. Are we all doing it wrong? Influence of stripping and cleaving methods of laser fibers on laser lithotripsy performance. J Urol 2015; 193 (03) 1030-1035
- 59 Shin RH, Lautz JM, Cabrera FJ. et al. Evaluation of novel ball-tip holmium laser fiber: impact on ureteroscope performance and fragmentation efficiency. J Endourol 2016; 30 (02) 189-194
- 60 Kwong RY, Ge Y, Steel K. et al. Cardiac magnetic resonance stress perfusion imaging for evaluation of patients with chest pain. J Am Coll Cardiol 2019; 74 (14) 1741-1755