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CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0044-1801823
Original Article

Perioperative Outcomes of Postmenopausal Women with Colorectal Cancer Undergoing Prophylactic Salpingo-oophorectomy

Eveline M. Schoenmaker
1   Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands
,
Jasper F. J. A. van Zon
1   Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands
,
Margot H. M. Heijmans
1   Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands
,
Johanne G. Bloemen
2   Department of Surgery, Catharina Cancer Institute, Eindhoven, The Netherlands
,
Tanja Lettinga
3   Department of Surgery, Sint Jans Gasthuis, Weert, The Netherlands
,
Jan-Willem D. de Waard
4   Department of Surgery, Dijklander Hospital, Hoorn, The Netherlands
,
Rudi M. H. Roumen
1   Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands
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Abstract

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Eveline M. Schoenmaker

Objectives Women with colorectal cancer have an increased risk of developing ovarian malignancies, which have a poor prognosis. Shared decision making on the possibility of prophylactic salpingo-oophorectomy (PSO) during colorectal cancer surgery in postmenopausal women has, therefore, been implemented. Effects of PSO on perioperative parameters are unknown. This study therefore compares perioperative parameters between women with and without PSO.

Materials and Methods Women undergoing colorectal cancer surgery between January 2020 and March 2023 in four centers in the Netherlands offering the possibility of PSO were included. Perioperative parameters were compared between the group with and without PSO.

Statistical Analysis Continuous data were analyzed with independent t-tests or nonparametric tests when applicable. Categorical variables were analyzed with chi-square tests. Propensity score matching was performed to control for potential confounders. The variables age, American Society of Anesthesiologists classification, TNM stages, and type of surgery were used as respective covariates. Perioperative data were again analyzed between the matched groups. A sensitivity analysis including all participants was performed to evaluate the effect of PSO on duration of admission and on complications.

Results The present study included 112 women who underwent PSO and 28 who did not. The PSO group was significantly younger (median: 74 vs. 79 years, p = 0.002), had a shorter hospital stay (median: 4 vs. 6 days, p = 0.006), and experienced less overall postsurgical complications (31 vs. 64%, p = 0.002). These differences were neither observed after propensity score matching nor after sensitivity analysis. Malignant adnexal tissue was identified in three patients.

Conclusion PSO in combination with elective colorectal cancer surgery in postmenopausal women does not lead to different or worse perioperative outcomes compared with the group without PSO. Nonetheless, the decision to undergo this combined surgery should be made on individual basis. Future research needs to focus on long-term follow-up and generalizability.

Keywords

prophylactic salpingo-oophorectomy - shared decision making - ovarian malignancies - colorectal cancer - surgical outcomes

Ethical Approval

Approval of the medical ethical committee was requested but formal approval was deemed unnecessary, according to Dutch law (METC Máxima MC). The study procedure was approved by the institutional review board of each participating hospital.


Author's Contribution

The study concepts were developed by E.S., J.Z., M.H., J.B., and R.R., while the study design was created by E.S., J.Z., M.H., and R.R. Data acquisition was carried out by E.S., J.Z., M.H., J.B., T.L., J.W., and R.R. E.S. and M.H. were responsible for the quality control of data and algorithms, and data analysis and interpretation were conducted by E.S., M.H., and R.R. Statistical analysis was performed by E.S. and M.H. The manuscript was prepared by E.S., edited by E.S., M.H., and R.R., and reviewed by J.Z., M.H., J.B., T.L., J.W., and R.R.




Publication History

Received: 14 August 2024

Accepted: 12 December 2024

Article published online:
17 January 2025

© 2025. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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