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CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0044-1801832
Original Article

The Effect of Topical Heparin Gel on Reducing Hand–Foot Syndrome Symptoms in Cancer Patients Treated with Capecitabine

Maede Mirjalili
1   Department of Internal Surgery Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
,
Yaser Salehinajafabadi
2   Department of Hematology and Oncology Surgery, Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
,
Hadi Raeisi Shahraki
3   Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
,
Rohollah Masumi
2   Department of Hematology and Oncology Surgery, Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
› Institutsangaben Funding This project was financially supported by Cancer Research Center, Shahrekord University of Medical Sciences (Grant No. 6371) and was approved under the ethics code IR.SKUMS.MED.REC.1401.045. The study is also registered with the Iranian Registry of Clinical Trials (IRCT) under the code IRCT20230215057423N1.
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Abstract

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Rohollah Masumi

Background and Aims Hand–foot syndrome (HFS) is a distinct and relatively frequent toxic skin reaction associated with certain chemotherapy agents, particularly capecitabine. Given the complications of this syndrome and the critical importance of timely and accurate treatment, the present study aims to investigate the efficacy of topical heparin gel in alleviating HFS in cancer patients undergoing treatment with capecitabine.

Methods A total of 40 patients with grade ⩽ 1 HFS associated with capecitabine were randomly assigned to intervention and control groups. The intervention group received heparin sulfate gel four times a day (21 days) along with capecitabine treatment, while the control group received only capecitabine and placebo gel. The changes in the severity of HFS and clinical manifestations, including erythema, swelling, blisters, hyperkeratosis, and bleeding, at baseline and 3 weeks posttreatment were evaluated. The data were subsequently validated by Fisher's or Chi-square tests.

Results At the beginning of the study, there were no significant differences between the two groups regarding disease manifestations. However, after the intervention, a significant difference was observed between the groups in terms of erythema and swelling (p = 0.001). There were no significant differences between the groups in other manifestations, such as blisters, bleeding, and scaling (p = 0.99). Comparison of the degree of HFS in the intervention group showed that 11 patients experienced improvement after the intervention, while all patients in the control group remained at the same degree of syndrome as before the intervention.

Conclusion The management of HFS in cancer treatment includes a combination of prevention, patient education, symptom improvement, and dose-intensity management. According to the results, it can be said that due to the positive effect of topical heparin gel in improving HFS caused by capecitabine and due to the absence of side effects, the use of topical heparin gel is recommended.

Key Points

  • Hand–foot syndrome (HFS) is a distinct and relatively frequent toxic skin reaction associated with capecitabine.

  • The efficacy of topical heparin gel in alleviating HFS in cancer patients was investigated.

  • Topical heparin gel is recommended due to its positive effect in improving HFS caused by capecitabine.

Keywords

topical - heparin sulfate gel - hand–foot syndrome - capecitabine - chemotherapy - cancer


Publikationsverlauf

Eingereicht: 22. August 2024

Angenommen: 12. Dezember 2024

Artikel online veröffentlicht:
24. Januar 2025

© 2025. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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