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CC BY 4.0 · Indian J Med Paediatr Oncol 2025; 46(02): 211-213
DOI: 10.1055/s-0045-1801886
Brief Communication

Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia

Swetha Palla 
1   Pediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
,
Parikshaa Gupta
2   Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Amita Trehan
1   Pediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
› Institutsangaben Funding None.
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Abstract

Central nervous system (CNS) infections are relatively common among children receiving treatment for acute lymphoblastic leukemia (ALL). However, diagnosing these infections presents challenges. In this report, we present a case of asymptomatic adenoviral meningitis, which presented a diagnostic challenge as it mimicked CNS involvement in a child undergoing treatment for ALL. Our findings underscore the importance of thorough diagnostic evaluation for CNS infections in children undergoing ALL therapy, whether they present with symptoms or exhibit asymptomatic cerebrospinal fluid pleocytosis. Furthermore, distinguishing between infections and CNS leukemia is critical, highlighting the necessity of employing flow cytometry to mitigate the potential misinterpretation of morphological features.

Keywords

acute lymphoblastic leukemia - CSF pleocytosis - CNS infection - CNS leukemia.

Patient Consent

Patient consent is not required in this study.


Author Contributions

S.P. wrote the manuscript, A.T. is the clinician involved in treatment and contributed to betterment of manuscript, P.G. is the Cytopathologist who reported the CSF samples and provided the required images.




Publikationsverlauf

Artikel online veröffentlicht:
04. Februar 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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