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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2025; 44(01): e24-e28
DOI: 10.1055/s-0045-1805015
Review Article

Prognostic Value of Neutrophil to Lymphocyte Ratio in Cerebral Venous Thrombosis Outcomes: Systematic Review

Valor prognóstico da relação neutrófilo-linfócito nos resultados da trombose venosa cerebral: Revisão sistemática
Pedro Lucas Carneiro Ferreira 
1   Faculty of Medicine, Universidade de Caxias do Sul (UCS), Rio Grande do Sul, RS, Brazil
,
Felipe Krieger Vargas
2   Faculty of Medicine, Universidade Franciscana (UFN), Rio Grande do Sul, RS, Brazil
,
Lucas Vieira Saueressig
2   Faculty of Medicine, Universidade Franciscana (UFN), Rio Grande do Sul, RS, Brazil
,
Fernando Bastiani Benetti
2   Faculty of Medicine, Universidade Franciscana (UFN), Rio Grande do Sul, RS, Brazil
,
Letícia Poletto Neves
1   Faculty of Medicine, Universidade de Caxias do Sul (UCS), Rio Grande do Sul, RS, Brazil
,
Adilson J.M. de Oliveira
3   Department of Neurosurgery, Neuroscience Centre, Clinica Girassol, Luanda, Angola
› Institutsangaben Funding None.
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Abstract

Introduction The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker that may be associated with the presence and degree of severity of vascular diseases and is a possible predictor of risk and mortality of cerebral venous thrombosis (CVT).

Methods Using PRISMA, the articles were evaluated based on sensitivity, specificity, cut-off, and AUC using the databases PUBMED and BVS. Inclusion criteria of articles were as follows: written in English, in cohort presentation, clinical trial, or control case with the key terms included in the abstract, title, or keywords of the selected articles.

Results A total of 700 articles were analyzed in the databases, obtained through the search string, and evaluated for the exclusion and inclusion criteria previously indicated. Four articles were included in the final analysis. The values of sensitivity (Sen) and specificity (Esp) differed among the articles analyzed, and three of the four articles showed higher specificity. Cut-off and AUC, likewise, differed in most articles, with a lower cut-off value of 2.1 and a higher value of 6.8. The AUC ranged from 0.71–0.77. The simple mean values for Sen and Esp were 62.8% and 78.7%, respectively.

Conclusion The data show that NLR can predict worse outcomes in CVT with moderate values of specificity and sensitivity (Ms Esp 78.7% / Ms Sen 62.8%).

Resumo

Introdução A razão neutrófilo-linfócito (NLR) é um marcador inflamatório que pode estar associado à presença e ao grau de gravidade de doenças vasculares e é um possível preditor de risco e mortalidade de trombose venosa cerebral (TVC).

Métodos Usando o PRISMA, os artigos foram avaliados com base na sensibilidade, especificidade, cut-off e AUC usando os bancos de dados PUBMED e BVS. Os critérios de inclusão dos artigos foram os seguintes: escritos em inglês, em apresentação de coorte, ensaio clínico ou caso controle com os termos-chave incluídos no resumo, título ou Palavras-chave dos artigos selecionados.

Resultados Um total de 700 artigos foram analisados nos bancos de dados, obtidos por meio da sequência de busca e avaliados para os critérios de exclusão e inclusão indicados anteriormente. Quatro artigos foram incluídos na análise final. Os valores de sensibilidade (Sen) e especificidade (Esp) diferiram entre os artigos analisados, e três dos quatro artigos apresentaram maior especificidade. O corte e a AUC, da mesma forma, diferiram na maioria dos artigos, com um valor de corte inferior de 2,1 e um valor superior de 6,8. A AUC variou de 0,71 a 0,77. Os valores médios simples para Sen e Esp foram 62,8% e 78,7%, respectivamente.

Conclusão Os dados mostram que a NLR é capaz de prever um pior resultado na TVC com valores moderados de especificidade e sensibilidade (Ms Esp 78,7% / Ms Sen 62,8%).

Keywords

cerebral venous thrombosis - neutrophil-lymphocyte ratio - inflammatory marker - prognosis - predictor of risk and mortality

Palavras-chave

trombose venosa cerebral - razão neutrófilo-linfócito - marcador inflamatório - prognóstico - preditor de risco e mortalidade


Publikationsverlauf

Eingereicht: 20. September 2023

Angenommen: 21. Oktober 2024

Artikel online veröffentlicht:
27. März 2025

© 2025. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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