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CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0045-1805081
Original Article

Association of SLC14A1C/T Polymorphisms in Patients with Bladder Cancer in Comparison with Healthy Controls

Saziya Bidi
1   Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital & Medical Research Centre, Nehru Nagar, Belagavi, Karnataka, India
2   Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-to-be-University), JNMC Campus, Belagavi, Karnataka, India
,
R.B Nerli
1   Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital & Medical Research Centre, Nehru Nagar, Belagavi, Karnataka, India
2   Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-to-be-University), JNMC Campus, Belagavi, Karnataka, India
,
Shadab Rangrez
3   Department of Biochemistry, JGMM Medical College, Hubballi, Karnataka, India
,
Shridhar C. Ghagane
1   Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital & Medical Research Centre, Nehru Nagar, Belagavi, Karnataka, India
4   KAHER's Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education & Research, JNMC Campus, Belagavi, Karnataka, India
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Abstract

Background

Transitional cell carcinoma of the urinary bladder is one of the most common malignancies affecting the urinary tract. Genomic instability is one of the most important common features of urothelial cancers of the bladder. Gene polymorphisms of the SLC14A1 gene are known to be related to carcinogenesis of the bladder in humans. Similarly, the use of tobacco products including chewing and smoking is an established risk factor for bladder cancer in both men and women. The primary aim of the study was to assess the relationship between bladder cancer and polymorphisms of the SLC14A1 gene (rs17674580) in our patients with image and histologically confirmed bladder cancer and secondarily to assess if use of tobacco products in these patients further accentuated the risk of bladder cancer.

Patients and Methods

All patients aged ≥18 years with images (ultrasonography/computed tomography) and histologically confirmed bladder cancer formed the study group. Age- and gender-matched individuals aged ≥18 years, genetically unrelated, formed the controls. A 2-mL blood sample was collected from patients as well as controls, for genotyping of SLC14A1C/T gene polymorphisms. Demographic data were obtained from all the participants, and individuals who smoked once a day for more than 5 years were defined as smokers. Similarly, patients who chewed tobacco for more than 5 years were defined as tobacco users.

Results

During the study period, 107 patients (84 males and 23 females) with image and histologically confirmed bladder cancer formed the study group. The mean age of the patients with bladder cancer was 58.47 ± 14.5 years and that of the controls was 60.01 ±  12.5 years. Among patients with bladder cancer, 28 (26.2%) showed no polymorphisms (rs17674580) of the SLC14A1 gene, whereas 79 (73.8%) patients showed polymorphisms. Heterozygous variations (CT) were noted in 46 (42.9%) patients, whereas homozygous variations were noted in 33 (30.9%) patients with the odds ratio being 2.772 (1.459–3.247) and 3.349 (1.610–6.922), respectively. The use of tobacco (smoking/chewing) was also found to modulate risks of bladder cancer in SLC14A1 variants.

Conclusion

Gene polymorphisms of SLC14A1C/T are associated with a high risk of bladder cancer in our group of patients in South India. Moreover, the use of tobacco, be it smoking or chewing, further increases the risk of bladder cancer in these patients.

Keywords

gene polymorphisms - transitional cell carcinoma - tobacco (smoking/chewing) - histopathology - south India


Publication History

Received: 08 May 2024

Accepted: 06 February 2025

Article published online:
07 March 2025

© 2025. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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