Synthesis of Heterocyclic Compounds with the Aid of Nitrile Oxides

Christoph GRUNDMANN

doi:10.1055/s-1970-21611

Synthesis 1970; 1970(7): 344-359
DOI: 10.1055/s-1970-21611

review

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Synthesis of Heterocyclic Compounds with the Aid of Nitrile Oxides

Christoph GRUNDMANN^*

^*Mellon Institute of Carnegie-Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania, 15213, USA

Abstract

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A number of recent preparative improvements have made nitrile oxides, R-C≡N→O, easily accessible starting materials for the synthesis of a wide variety of heterocyclic systems, some of them almost inaccessible by any other route. The vast majority of the reactions discussed in this review are 1,3-dipolar cycloadditions leading to five-membered rings. The survey concludes with a selected number of reactions which do not fall under the above classification, but which are considered to be of preparative interest.

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