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Synthesis 1971; 1971(10): 501-526
DOI: 10.1055/s-1971-21765
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Die Hypojodit-Reaktion (Verfahren zur intramolekularen Substitution an nicht-aktivierten C-Atomen)

J. KALVODA* , K. HEUSLER
  • *Chemische Forschungslaboratorien der Division Pharmazeutika der CIBA-GEIGY Aktiengesellschaft, CH-4000 Basel (Schweiz).
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Publikationsdatum:
12. September 2002 (online)

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The Hypoiodite Reaction (HR) is one of the most versatile methods for intramolecular substition on non-activated centers. It can be used for the synthesis of various classes of compounds, such as tetrahydrofurans, lactones, γ-cyanoketones, etc. In the present review article, practical and theoretical aspects of the hypoiodite reaction are discussed and illustrated by appropriate experimental procedures.