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Synthesis 1975; 1975(8): 483-495
DOI: 10.1055/s-1975-23813
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Synthesis of Heterocycles via Cycloadditions to 1-Azirines

David J. ANDERSON* , Alfred HASSNER
  • *Department of Chemistry, University of Colorado, Boulder, Colorado 80302, U.S.A.
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Publication Date:
12 September 2002 (online)

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The wide applicability of 1-azirines as reagents for the syntheses of many well-known and novel heterocyclic systems is discussed in this article. Although most work has been concentrated on thermal and photochemical cycloaddition reactions of 1-azirines, reactions which proceed via C-N-, N =C-, or C-C-bond cleavage are included. Also, reactions which proceed formally via cycloaddition but give rise to open-chain products are also described. 1. Carbenoid Additions 2. 1,3-Dipolar Reactions 3. Diels-Alder Reactions 4. Ketenes and Ketenimine Additions 5. Isocyanate Additions 6. Miscellaneous Additions 7. Photochemical Cycloadditions