Recent Synthetic Methods for Polyfluoroaromatic Compounds

This review describes processes for introducing fluorine atoms on to the aromatic nucleus. Methods for the preparation of a great number of polyfluorinated aromatic compounds involving the action of nucleophilic, electrophilic, and radical agents on polyfluoroaromatic compounds are discussed. The synthetic uses of the anomalous behaviour of functional groups adjacent to the fluorinated aromatic nuclei are also discussed. 1. Methods for the Fluorination of Aromatic Compounds 2. Reactions of Polyfluoroaromatic Compounds 2.1. Action of Nucleophilic Agents 2.2. Action of Electrophilic Agents 2.3. Action of Radicals and Carbenes 3. Transformations of Functional Groups Adjacent to the Polyfluorinated Aromatic Nucleus 3.1. Reactions of Hydrogen Atoms 3.2. Reactions of Halogen Atoms (other than Fluorine) 3.3. Reactions of Alkyl Groups 3.4. Reactions of Carbonyl-Containing Compounds 3.5. Reactions of Carboxyl Groups 3.6. Reactions of Nitrogen-Containing Compounds 3.7. Reactions of Hydroxy- and Sulphur-Containing Groups