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Synthesis 1985; 1985(12): 1159-1161
DOI: 10.1055/s-1985-31463
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p-Toluenesulfonic Acid Adsorbed on Silica Gel: An Efficient Dehydrating Agent of Alcohols

Franco D'Onofrio* , Arrigo Scettri
  • *Centro di Studio per la Chimica delle Sostanze Organiche Naturali del CNR, Dipartimento di Chimica dell'Università "La Sapienza", Piazzale A. Moro 5, I-00185 Rome, Italy
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Publikationsdatum:
27. September 2002 (online)

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Secondary and tertiary alcohols are efficiently dehydrated by reaction with p-toluenesulfonic acid supported on silica gel. In particular, the procedure allows the direct conversion of 3-hydroxy-steroids into Δ2-olefins or Δ3,5-dienes, without passing through the mesylate or tosylate esters.