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Synthesis 1986; 1986(4): 288-291
DOI: 10.1055/s-1986-31586
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A New, Convenient Synthesis of N 2-Aryl-N 1-alkylformamidines and N 2-Aryl-N 1,N 1-dialkylformamidines

Enzo Cereda* , Elio Bellora, Arturo Donetti
  • *Chemical Research Department of Istituto De Angeli, Via Serio 15, I-20139 Milano, Italy
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Publication Date:
27 September 2002 (online)

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N 2-Aryl-N 1-alkylformamidines are conveniently and rapidly prepared by the reaction of an aromatic amine with ethyl N-cyanoformimidate to give the N 2-aryl-N 1-cyanoformamidine. Addition of this intermediate to an excess of an alkyl- or dialkylamine results in the formation of the title compounds in high yield and satisfactory purity. A mechanism for this reaction is proposed and discussed.