Download PDF
Synthesis 1986; 1986(5): 400-402
DOI: 10.1055/s-1986-31651
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Facile Synthesis of Polyfunctionally Substituted Pyridines from Ethoxycarbonylmalonaldehyde

Sigeru Torii* , Tsutomu Inokuchi, Minoru Kubota
  • *Department of Industrial Chemistry, School of Engineering, Okayama University, Okayama 700, Japan
Further Information

Publication History

Publication Date:
27 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A facile access to 2,3-disubstituted-5-ethoxycarbonylpyridines (50-66% yields), derivatives of biologically and medicinally important nicotinic acid, is explored. The method involves the reaction of ethoxycarbonylmalonaldehyde with tosyl chloride and then with β-amino-α,β-unsaturated esters, ketones, or nitriles in the presence of pyridine.