PDF herunterladen
Synthesis 1986; 1986(5): 403-406
DOI: 10.1055/s-1986-31653
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Practical Synthesis of Some Versatile Chiral Building Blocks from (D)-Mannitol

Seiichi Takano* , Ayako Kurotaki, Michiyasu Takahashi, Kunio Ogasawara
  • *Pharmaceutical Institute, Tohoku University. Aobayama, Sendai 980, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
27. September 2002 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

The three chiral building blocks ethyl 4,5-O-isopropylidene-(E)-(S)-4, 5-dihydroxy-2-pentenoate [1,3-dioxolane derivative (E)-(S)-1a], (S)-5-hydroxy-4-pentanolide [(S)-2a], and (S)-5-hydroxy-2-penten-4-olide [(S)-3a] are conveniently prepared from 1,2;5,6-di-O-isopropylidene-D-mannitol (4) via a glycol cleavage and Horner-Emmons reaction sequence.