Synthesis 1986; 1986(5): 409-411
DOI: 10.1055/s-1986-31655
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Pyrrole and Pyrazole Ring Closure in Heterogeneous Media

F. Texier-Boullet* , B. Klein, J. Hamelin
  • *Groupe de Recherche de Physicochimie Structurale, no 3, Unité associée au CNRS no 704, Université de Rennes I, Campus de Beaulieu, F-35042 Renees Cedex, France
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Publication History

Publication Date:
27 September 2002 (online)

Pyrroles and pyrazoles may be conveniently prepared by dispersing primary amines or hydrazines and 1,4- or 1,3-diketones, respectively, on alumina or clay (montmorillonite K 10) without solvent, keeping the mixture at 20°C or higher temperatures for 1-26 h, and then eluting the product with dichloromethane.