Download PDF
Synthesis 1986; 1986(5): 427-429
DOI: 10.1055/s-1986-31667
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

The Synthesis of Highly Functionalized Naphthalene Derivatives

Simon J. Teague* , Gregory P. Roth
  • *Department of Chemistry, Colorado State University, Ft. Collins, Colorado 80523, U. S. A.
Further Information

Publication History

Publication Date:
27 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Condensation of the α-lithio derivative of 3-substituted 4,4-dialkoxybutanoates, butanenitriles, and butanamides with methoxy-activated aromatic aldehydes, followed by treatment with refluxing dilute sulfuric acid gives rise to substituted naphthalene products. In this manner, 2,6,7-tri- and 2,3,6,7-tetrasubstituted naphthalenes are synthesized in high yields on a multigrarn scale.