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Synthesis 1986; 1986(8): 642-643
DOI: 10.1055/s-1986-31729
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Reactions in Slightly Hydrated Solid/Liquid Heterogeneous Media: The Methylation Reaction with Dimethyl Sulfoxide

D. Achet* , D. Rocrelle, I. Murengezi, M. Delmas, A. Gaset
  • *Laboratoire de Chimie des Agrorssources, Institut National Polytechnique, E. N. S. C. 118, route de Narbonne, F-31077 Toulouse Cédex, France
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Publication Date:
22 August 2002 (online)

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The O-methylation of alcohols and phenols with stoichiometric amounts of dimethyl sulfate in 1,4-dioxan or triglyme in the presence of solid potassium hydroxide and small amounts of water represents a useful method for the synthesis of methylethers in high yields and with high selectivity. The complete consumption of dimethyl sulfate in this reaction avoids the problems connected with the work-up of reaction mixtures still containing excess amounts of this toxic reagent.