Synthesis of 1-Hydroxyphenyl-Substituted 6-Alkoxycarbonyl (and 6-Carbamoyl)-2-Pyridone-4,5-Dicarboxylic Acid Dimethyl Esters

Norio Kawahara; Takako Nakajima; Tsuneo Itoh; Haruo Ogura

doi:10.1055/s-1986-31731

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Synthesis 1986; 1986(8): 644-645
DOI: 10.1055/s-1986-31731

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Synthesis of 1-Hydroxyphenyl-Substituted 6-Alkoxycarbonyl (and 6-Carbamoyl)-2-Pyridone-4,5-Dicarboxylic Acid Dimethyl Esters

Norio Kawahara^* , Takako Nakajima, Tsuneo Itoh, Haruo Ogura

^*Hokkaido Institute of Pharmaceutical Sciences, 7-1, Katsuraokacho, Otaru-shi, Hokkaido 047-02, Japan

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Publication Date:
22 August 2002 (online)

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A new and convenient synthesis of dimethyl 1-hydroxyphenyl-2-pyridone-4, 5-dicarboxylate derivatives 4-6 from o-aminophenols and dimethyl acetylenedicarboxylate is reported.