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Synthesis 1986; 1986(9): 765-766
DOI: 10.1055/s-1986-31770
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Enamines; 451. A New Simple Synthesis of 2-Phenyl- succinic Acids

Elisabetta Rossi* , Silvia Sassano, Riccardo Stradi
  • *Istituto di Chimica Organica della Facoltà di Farmacia. Università di Milano, Viale Abruzzi 42, I-20131 Milano, Italy.
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Publikationsdatum:
20. August 2002 (online)

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A simple route to 2-phenylsuccinic acids consists of the reaction of 1,1-dimorpholinoethene with ß-nitrostyrenes at room temperature and hydrolysis of the 1:1 adduct thus obtained with hydrochloric acid. The method affords good overall yields of 2-phenylsuccinic acids.