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Synthesis 1986; 1986(10): 859-860
DOI: 10.1055/s-1986-31807
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Synthese neuer 1,6-Naphthyridine durch Aminomethin-ylierung von 1,4-Dihydropyridinen

J. Kleinschroth* , K. Mannhardt, J. Hartenstein, G. Satzinger
  • *Gödecke Forschungsinstitut, Mooswaldallee 1 -9, D-7800 Freiburg, West Germany
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Publication Date:
20 August 2002 (online)

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Synthesis of New 1,6-Naphthyridines by Aminomethinylation of 1,4-Dihydropyridines 1,4-Dihydropyridines (1a-h) react with s-triazine in the presence of base to give 1,4-dihydro-1,6-naphthyridinones (2a-h) in a single step in fair to good yields. The title compounds can also be prepared by reaction of 1,4-dihydropyridines with amidacetals followed by treatment of the aminomethylene intermediates (4) with ammonia.