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Synthesis 1986; 1986(12): 1044-1045
DOI: 10.1055/s-1986-31868
DOI: 10.1055/s-1986-31868
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One-Step Synthesis of Methyl 2-Arylpropanoates from 2-Hydroxypropiophenone Dimethylacetals using Sulfuryl Chloride and an Amide or a Weak Base
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Publication History
Publication Date:
12 September 2002 (online)
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A facile one-pot method for the preparation of methyl 2-aryl-propanoates 3 from 2-hydroxypropiophenones dimethyl acetals 1 using sulfuryl chloride, pyridine, and dichloromethane is reported. Yields range from 54 to 87% for the aryl groups: phenyl, 4-bromophenyl, 4-methoxyphenyl, 4-isobutylphenyl, and 4-biphenylyl.