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Synthesis 1987; 1987(1): 28-32
DOI: 10.1055/s-1987-27830
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Enantioselective Reduction of Vicinally Substituted Monocyclic Aldehydes with Horse Liver Alcohol Dehydrogenase; A New Approach to Chiral Alcohols and Aldehydes

Wilhelm Boland* , Uwe Niedermeyer
  • *Institut für Biochemie, An der Bottmühle 2, D-5000 Köln 1, West Germany
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Publication History

Publication Date:
20 August 2002 (online)

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Optically active, vicinally substituted monocyclic aldehydes and alcohols can be conveniently prepared by enantioselective reduction of racemic aldehydes by means of horse liver alcohol dehydrogenase (HLADH) under kinetically controlled conditions.