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Synthesis 1987; 1987(3): 233-236
DOI: 10.1055/s-1987-27899
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Amino Acids and Peptides; 59.1 Synthesis of Biologically Active Cyclopeptides; 9.2 Synthesis of 16 Isomers of Dolastatin 3;3 I. Synthesis of the 2-(1-aminoalkyl)-thiazole-4-carboxylic Acids

Ulrich Schmidt* , Roland Utz, Albrecht Lieberknecht, Helmut Griesser, Bernd Potzolli, Johanna Bahr, Karin Wagner, Peter Fischer
  • *Institut für Organische Chemie, Biochemie und Isotopenforschung der Universität Stuttgart, Pfaffenwaldring 55, D-7000 Stuttgart 80, West Germany
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Publication Date:
12 September 2002 (online)

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The synthesis of the optically active Dolastatin 3 building block 2-(1-amino-3-cyanopropyl)-thiazole-4-carboxylic acid is described as a prerequisite for the total synthesis of dolastatin isomers.