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Synthesis 1987; 1987(3): 256-258
DOI: 10.1055/s-1987-27906
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A Rapid and Efficient Synthesis of Sulfur Analogues of Pyrimidine Bases

Andrzej R. Łapucha*
  • *Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, Pl-60-780 Poznań, Poland
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Publication Date:
12 September 2002 (online)

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An improved procedure for thionation of some natural pyrimidine bases with tetraphosphorus decasulfide/sodium hydrogen carbonate is reported. Some substituted uracils and 2-thiouracils were converted into a series of analogues in which the oxygen at position 4 was replaced by sulfur atom. The advantage of this method of thionation over the older procedures is based on the tetraphosphorus decasulfide/sodium hydrogen carbonate mixture giving rise to excellent yields and simplified isolation of the desired pure products.