PDF herunterladen
Synthesis 1987; 1987(3): 260-262
DOI: 10.1055/s-1987-27908
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Verbesserte Synthese von 7,7-Difluorcyclopropabenzol

C. Glück* , V. Poignée, H. Schwager
  • *Pharmazeutisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 364, D-6900 Heidelberg, West Germany
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
12. September 2002 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Improved Synthesis of 7,7-Difluorocyclopropabenzene A five-step, optimised sequence for the preparation of the title compound is reported. Trichloroethylene is converted to 1,6-dichloro-7,7-difluorobicyclo[4.1.0]hept-3-ene (5) via pentachlorocyclopropane, tetrachlorocyclopropene, and 1,2-dichloro-3,3-difluorocyclopropene by modifications of the procedures reported by Tobey and coworkers. Final dehydrochlorination of 5 allows the production of 7,7-difluorocyclopropabenzene in 50 g quantities.