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Synthesis 1987; 1987(3): 278-280
DOI: 10.1055/s-1987-27916
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Synthesis of 6-Substituted Purines From 3,7-Dimethyl-6-methylthio-2-oxopurine

Mikio Hori* , Tadashi Kataoka, Hiroshi Shimizu, Eiji Imai, Masaharu Yokomoto, Yasuhiko Ando
  • *Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5-chome, Gifu 502, Japan
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Publication Date:
12 September 2002 (online)

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Nucleophilic substitution of 3,7-dimethyl-6-methylthio-2-oxopurine (1) with alcoholates or carbanions of active methylene compounds affords the corresponding 6-alkoxy- or 6-alkylidene-3,7-dimethyl-2-oxopurines, respectively, in good yields.