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Synthesis 1987; 1987(5): 495-496
DOI: 10.1055/s-1987-27981
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A Simple Synthesis of 5-(1-Alkenyl)uracil Derivatives by Palladium-Catalyzed Oxidative Coupling of Uracils With Olefins

Kosaku Hirota* , Yoshiaki Isobe, Yukio Kitade, Yoshifumi Maki
  • *Gifu Pharmaceutical University, Mitahora-Higashi, Gifu 502, Japan
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Publication Date:
18 September 2002 (online)

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The oxidative coupling of uracil derivatives t with olefins, such as methyl acrylate, acrylonitrile, methyl vinyl ketone, and styrene, using one equivalent of palladium acetate leads to the corresponding 5-(1-alkenyl)uracil derivatives 2.