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Synthesis 1987; 1987(10): 917-920
DOI: 10.1055/s-1987-28122
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2-Chloro-4,6-dimethoxy-1,3,5-triazine. A New Coupling Reagent for Peptide Synthesis

Zbigniew J. Kamiński*
  • *Institute of Organic Chemistry, Technical University of Łódź, PL-90-924 Łódź, Poland
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Publication Date:
12 September 2002 (online)

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In order to facilitate the purification of peptides, the new coupling reagent 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) is proposed. Due to the weakly basic properties of the triazine ring, the side products and excess coupling reagent are easily removed by washing the crude reaction product with diluted acids. CDMT enables the synthesis of di-,tri-, and pentapeptides in 75-98% yield under mild conditions and without concomitant racemization. Moreover, the reagent diminishes the formation of side products during the incorporation of serine with an unprotected hydroxy group or of N-protected ω-nitroarginine into the peptide chain.