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Synthesis 1987; 1987(11): 1031-1032
DOI: 10.1055/s-1987-28162
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New Methods for the Preparation 2-Formyl-1,2,3,4-tetrahydroisoquinolines via N-Formyliminium Ions

Ludmil K. Lukanov* , Athanas P. Venkov, Nikola M. Mollov
  • *University of Plovdiv 4000 Plovdiv, Bulgaria
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Publication Date:
12 September 2002 (online)

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N-Formyl-2-phenylethylamines react with different aldehydes in acidic medium giving good yields of 2-formyl-1,2,3,4-tetrahydroisoquinolines. In situ prepared N-formyl-2-phenylethylamine (from phenethylamines in formic acid as the reaction medium) can also be used for the synthesis of the title compounds.