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Synthesis 1987; 1987(12): 1124-1126
DOI: 10.1055/s-1987-28195
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Facile Synthesis of Annelated NADH Model Precursors

R. Benoit* , G. Dupas, J. Bourguignon, G. Quéguiner
  • *Laboratoire de Chimie Organique Fine et Hétérocyclique, INSA-IRCOF BP 08, F-76130 Mont Saint Aignan, France
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Publikationsdatum:
20. August 2002 (online)

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A convenient route to γ-cyano fused pyridine derivatives, which are precursors of NADH models, is described. The method involves the reaction of 3,3-dimethoxy-2-formyl-propionitrile sodium salt (1) with amino derivatives of electron donating heterocycles leading to the desired products by an easy one-pot synthesis.