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Synthesis 1988; 1988(2): 138-140
DOI: 10.1055/s-1988-27492
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A One-Pot Synthesis of β-Acylenamines

Souheir El Cherif* , Loïc René
  • *INSERM, Pharmacologie, 17 rue du Fer à Moulin, F-75005 Paris, France
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Publication History

Publication Date:
20 August 2002 (online)

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β-Acylenamines (β-amino α,β-unsaturated ketones) 4 are prepared in good yields in a Mannich reaction by heating a mixture of ketone 1, triethyl orthoester 2 and secondary amine 3 in a pressure vessel.