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Synthesis 1988; 1988(3): 194-198
DOI: 10.1055/s-1988-27510
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Über eine neue Methode zur positionsselektiven Einführung von Trifluormethyl-Gruppen in Heteroaromaten, Teil 2.1 Nucleophile Substitution an 5-fluor-4-trifluormethyl-substituierten 1,3-Azolen

Klaus Burger* , Dieter Hübl, Klaus Geith
  • *Institut für Organische Chemie der Technischen Universitä München, Lichtenbergstraße 4, D-8046 Garching, Federal Republic of Germany
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Publication Date:
20 August 2002 (online)

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A New Method for Regioselective Introduction of Trifluoromethyl Groups into Heteroarenes; Part2. Nucleophilic Substitution of 5-Fluoro-4- trifluoromethyl-1,3-azoles 5-Fluoro-4-trifluoromethyl-1,3-azoles are readily susceptible to nucleophilic displacement reactions at C-5. With binucleophiles, the reactioncan be used for linking trifluoromethyl-substituted 1,3-azoles to aromatic, heteroaromatic, and heterocyclic systems, linearly or angularly,directly or across various bridging groups respectively.