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Synthesis 1988; 1988(3): 226-228
DOI: 10.1055/s-1988-27521
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Preparation of Derivtives of (R)-1,2,4-Butanetriol from L-Ascorbic Acid

Kin-Chun Luk* , Chung-Chen Wei
  • *Hoffmann-La Roche, Inc., Anti-Infective Chemistry, Chemistry Research Department, Nutley, NJ 07110, USA
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Publikationsdatum:
20. August 2002 (online)

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Methyl 3,4-O-isopropylidene L-threonate (3), obtained from L-ascorbic acid, was converted to its O-phenyl thiocarbonate 4. Deoxygenation of 4 with tri-n-butyltin hydride gave the protected 3,4-dihydroxybutanoate 5, which was converted to the (R)-1,2,4-butanetriol derivatives 6 and 7.