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Synthesis 1988; 1988(3): 238-240
DOI: 10.1055/s-1988-27528
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A New Method for the Synthesis of α-Substituted Phenethylamines via Titanium Amide Complexes

Hiroshi Takahashi* , Takeshi Tsubuki, Kimio Higashiyama
  • *Institute of Medicinal Chemistry, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo 142, Japan
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Publication Date:
20 August 2002 (online)

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Substituted phenethylamines (1-substituted 2-phenylethylamines) 4 are obtained in high yields by a new, facile reaction of titanium amide complexes with aldehydes and benzylmagnesium chloride.