Download PDF
Synthesis 1988; 1988(3): 257-259
DOI: 10.1055/s-1988-27537
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Facile Synthesis of 4-Hydroxycoumarins by Sulfur-Assisted Carbonylation of 2′-Hydroxyacetophenones with Carbon Monoxide

Takumi Mizuno* , Ikuzo Nishiguchi, Tsuneaki Hirashima, Akiya Ogawa, Nobuaki Kambe, Noboru Sonoda
  • *Osaka Municipal Technical Research Institute, 1-6-50, Morinomiya, Jyoto-ku, Osaka 536, Japan
Further Information

Publication History

Publication Date:
20 August 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

4-Hydroxycoumarins (4-hydroxy-2-oxo-2H-1-benzopyrans) were synthesized in good to excellent yields by C-carbonylation of 2′-hydroxyacetophenones with carbon monoxide in the presence of sulfur and bases. This is the first example of sulfur-assisted C-Carbonylation with carbon monoxide.