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Synthesis 1988; 1988(4): 325-327
DOI: 10.1055/s-1988-27558
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2-Substituted Glutarimides via Preformed Wittig Reagents

M. J. Wanner* , G. J. Koomen
  • *Lab of Organic Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, NL-1018 WS Amsterdam, The Netherlands
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Publication Date:
20 August 2002 (online)

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Triphenylphosphoranylideneacetamide (1) reacts with some Michael-acceptors to give crystalline 2-triphenylphosphoranylidene glutarimides. The Wittig reaction of 2 with several aldehydes in refluxing 1,2-dichloroethane affords the corresponding 2-alkylideneglutarimides 7 in 50-98% yield.