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Synthesis 1988; 1988(5): 401-402
DOI: 10.1055/s-1988-27592
DOI: 10.1055/s-1988-27592
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A Facile Synthesis of (S)-Isoserine from (S)-Malic Acid
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Publication History
Publication Date:
20 August 2002 (online)
Reaction of (S)-malic acid 1-monobenzyl ester with diphenoxyphosphoryl azide in the presence of triethylamine gives benzyl (S)-2-oxooxazolidine-5-carboxylate, which is readily converted into (S)isoserine by alkaline hydrolysis.