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Synthesis 1988; 1988(6): 456-459
DOI: 10.1055/s-1988-27605
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Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

C. R. Rasmussen* , F. J. Villani, Jr., L. E. Weaner, B. E. Reynolds, A. R. Hood, L. R. Hecker, S. O. Nortey, A. Hanslin, M. J. Costanzo, E. T. Powell, A. J. Molinari
  • *Department of Chemical Research, Janssen Research Foundation, Spring House, PA 19477-0776, USA
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Publikationsdatum:
20. August 2002 (online)

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An improved procedure for the preparation of arylthioureas consists of the reaction of benzoyl isothiocyanate with anilines in acetone and debenzoylation of the resultant N-aryl-N′-benzoylthioureas with 5% aqueous sodium hydroxide. Bicycloalkylthioureas and N-(arylalkyl)thioureas (e.g., 9H-9-fluorenylthiourea) are directly prepared from the corresponding isothiocyanates and ammonia.