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Synthesis 1988; 1988(8): 599-604
DOI: 10.1055/s-1988-27648
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A Novel, Convenient Synthesis of 2-Aryl-3-oxo-3,4-dihydro-2H-1,4-benzothiazines

Masanobu Fujita* , Atsutoshi Ota, Susumu Ito, Koji Yamamoto, Yoichi Kawashima
  • *Research Laboratory, Santen Pharmaceutical Co., Ltd., 9-19, Shimoshinjo 3-chome, Higashi Yodogawa-ku, Osaka, Japan
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Publication Date:
20 August 2002 (online)

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A novel method for the synthesis of 2-aryl-3-oxo-3,4-dihydro-2H-1, 4-benzothiazines consists of a Friedel-Crafts type reaction of substituted benzenes with 2-chloro-3-oxo-3,4-dihydro-2H-1,4-benzothiazines. This method is convenient by virtue of its simplicity and the good yields.