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Synthesis 1988; 1988(8): 608-610
DOI: 10.1055/s-1988-27650
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Preparative-Scale, Facile Synthesis of (2R,4E)-2-Methyl-4-hexenal: A Key Intermediate of (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-methylamino-6-octenoic Acid (MeBmt)

Donald T. Deyo* , Johannes D. Aebi, Daniel H. Rich
  • *School of Pharmacy, University of Wisconsin, Madison, WI 53706, USA
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Publication Date:
20 August 2002 (online)

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Facile separation and mild acidic hydrolysis of the diastereomeric amides derived from 2-methyl-4-hexenoic acid and L-2-phenylglycinol are used in a rapid, preparative-scale synthesis of (2R,4E)-2-methyl-4-hexenal, a key intermediate of MeBmt.