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Synthesis 1988; 1988(8): 614-615
DOI: 10.1055/s-1988-27653
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Synthesis of α-Trifluoromethylated Carboxylic Acid Esters

Tomoya Kitazume* , Takeshi Ohnogi
  • *Department of Bioengineering, Tokyo Institute of Technology Ookayama, Meguro-ku, Tokyo 152, Japan
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Publication History

Publication Date:
20 August 2002 (online)

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A series of menthyl 2-(trifluoromethyl)alkanoates were prepared by reaction of menthyl 2-(trifluoromethyl)propenoates with dialkyl- or diphenylcuprates and hydrofluorination of the menthyl 2-(difluoromethylene)alkanoates thus obtained by addition of tetrabutylammonium fluoride followed by hydrolysis.