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Synthesis 1988; 1988(12): 1011-1012
DOI: 10.1055/s-1988-27791
DOI: 10.1055/s-1988-27791
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The Efficient Synthesis of 3-Arylsydnones Under Neutral Conditions
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Publication History
Publication Date:
20 August 2002 (online)
Various substituted aryl sydnones can be prepared in high yield under mild, neutral conditions by nitrosation of the appropriate aryl glycine with isoamyl nitrite in dimethoxyethane followed by cyclization with trifluoroacetic anhydride.