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Synthesis 1989; 1989(1): 37-39
DOI: 10.1055/s-1989-27139
DOI: 10.1055/s-1989-27139
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A Simple Method for Amide Formation from Protected Amino Acids and Peptides
Further Information
Publication History
Publication Date:
27 September 2002 (online)
Amide formation from protected amino acids and peptides is directly and simply achieved by using 1-hydroxybenzotriazole as activating agent and treating the intermediate O-(benzotriazol-1-yl) derivative ("active ester") in situ with 25% ammonium hydroxide solution.