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Synthesis 1989; 1989(1): 50-51
DOI: 10.1055/s-1989-27148
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Simple One-Pot Synthesis of 2-Acylmethylidene-3-methylthiazolines

Henry W. Pauls* , Allen Krantz
  • *Syntex Research (Canada), 2100 Syntex Court, Mississauga, Ontario, L5N 3X4, Canada
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Publication History

Publication Date:
27 September 2002 (online)

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2-Acylmethylidene-3-methylthiazolines 3 (R = alkyl or aryl) are obtained from their precursor acids in one operation. Carboxylic acids 1 are activated with carbodiimide, and treated, in situ, in the presence of 4-dimethylaminopyridine, with 3-methyl-2-methylidene-4-thiazoline (6) (derived from thiazolium salt 2) to yield 2-acylmethylidene-3-methylthiazolines 3.