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Synthesis 1989; 1989(3): 197-198
DOI: 10.1055/s-1989-27194
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A Practical Method for Synthesis of Penicillin and Cephalosporin Sulfoxides

Mamoru Tanaka* , Toshiro Konoike, Mitsuru Yoshioka
  • *Production Department, Shionogi & Co., Ltd., Terajima 2-1-3, Kuise, Hyogo 660, Japan
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Publikationsdatum:
17. September 2002 (online)

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Penicillin and cephalosporin esters 1 and 3 are oxidized to the corresponding sulfoxides 2 and 4 by a safe and inexpensive method using a reagent mixture of hydrogen peroxide (35%), formic acid and polyphosphoric acid.

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