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Synthesis 1989; 1989(4): 262-265
DOI: 10.1055/s-1989-27217
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Synthesis of Pyrrole-3,4-diacetic Acid and Its Derivatives

Gian Paolo Chiusoli* , Mirco Costa, Sara Reverberi
  • *Istituto di Chimica Organica dell 'Universita', Viale delle Scienze, I-43100 Parma, Italy
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Publikationsdatum:
17. September 2002 (online)

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A simple procedure for the synthesis of pyrrole-3,4-diacetic esters and N-derivatives thereof consists of the oxidative alkoxycarbonylation of dipropargylamine or N-derivatives to give 3,4-bis(alkoxycarbonylmethylene) pyrrolidines which can be easily isomerized to pyrrole-3,4-diacetic esters. Controlled hydrolysis of these esters affords pyrrolidine-3,4-diacetic acid.