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Synthesis 1989; 1989(4): 265-268
DOI: 10.1055/s-1989-27218
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Synthesis of Esters of Lipophilic Proline Analogs by Reduction of Ethyl 5,6- Dihydro-4H-1,2-oxazine-3-carboxylates

Rainer Henning* , Ulrich Lerch, Hansjörg Urbach
  • *Hoechst AG, Postfach 80 03 20, D-6230 Frankfurt/Main 80, Federal Republic of Germany
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Publication Date:
17 September 2002 (online)

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Ethyl esters of proline substituted with lipophilic residues in 4- and/or 5-position are obtained via catalytic hydrogenation of the corresponding ethyl 5,6-dihydro-4H-1,2-oxazine-3-carboxylates.