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Synthesis 1989; 1989(4): 280-282
DOI: 10.1055/s-1989-27222
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Synthesis of 4-Oxo-3,4-dihydro-1H-thieno[3,4-c]- and thieno [3,2-c][1,2,6]thiadiazine 2,2-Dioxides

Pilar Goya* , Jaime Lissavetzky, Isabel Rozas
  • *Instituto de Química Médica (CSIC), Juan de la Cierva 3, E-28006-Madrid, Spain
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Publication Date:
17 September 2002 (online)

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4-Oxo-3,4-dihydro-1H-thieno[3,4-c][1,2,6]thiadiazine 2,2-dioxide (3) has been synthesized in a two-step approach involving sulfamoylation of 3-amino-4-methoxycarbonylthiophene (1) and subsequent ring closure. A modification of this procedure, which involves isolation of the intermediate thiophenecarboxylic acid derivatives 4 and 9 has been used to prepare new 4-oxo-3,4-dihydro-1H-thieno[3,4-c]- and thieno[3,2-c][1,2,6]thiadiazine 2,2-dioxides 6 and 10 respectively.