Dealkylation of Activated Alkyl Aryl Ethers Using Lithium Chloride in Dimethylformamide

Angela M. Bernard; M. Rossella Ghiani; Pier Paolo Piras; Antonio Rivoldini

doi:10.1055/s-1989-27225

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Synthesis 1989; 1989(4): 287-289
DOI: 10.1055/s-1989-27225

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Dealkylation of Activated Alkyl Aryl Ethers Using Lithium Chloride in Dimethylformamide

Angela M. Bernard^* , M. Rossella Ghiani, Pier Paolo Piras, Antonio Rivoldini

^*Istituto di Chimica Farmaceutica, Tossicologica ed Applicata, Università di Cagliari, Via Ospedale 72, I-09100 Cagliari, Italy

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Publication Date:
17 September 2002 (online)

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Alkyl aryl ethers having electron-withdrawing substituents in the ortho or para positions are easily cleaved with lithium chloride in dimethylformamide.